Studies of Skin Carcinogenesis in the Syrian Golden Hamster*
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چکیده
The carcinogens 9,10-dime thy 1-1,2-benzanthracene, 20-methylcholanthrene, 3,4benzpyrene, 1,2,5,6-dibenzanthracene, 1,2-benzanthracene, and 2-anthramine have been tested topically in the Syrian golden hamster. The mouse skin tumor-promoting agents, croton oil and polyoxyethylene sorbitan monostearate (Tween 60), have been tested on hamster skin following a single applica tion of 9,10-dimethyl-l,2-benzanthracene. Melanotic tumors, similar to those previously described, were induced with 9,10dimethyl-1,2-benzanthracene. Among the other carcinogens tested, only 20-methyl cholanthrene gave rise to a single melanotic tumor. The results are discussed in terms of chemical specificity and dose-response for the induction and progression of the melanotic tumors, in contrast to other skin tumors.
منابع مشابه
Studies of skin carcinogenesis in the Syrian golden hamster.
The carcinogens 9,10-dime thy 1-1,2-benzanthracene, 20-methylcholanthrene, 3,4benzpyrene, 1,2,5,6-dibenzanthracene, 1,2-benzanthracene, and 2-anthramine have been tested topically in the Syrian golden hamster. The mouse skin tumor-promoting agents, croton oil and polyoxyethylene sorbitan monostearate (Tween 60), have been tested on hamster skin following a single applica tion of 9,10-dimethyl-l...
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